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Chlorcyclizine hydrochloride

CAS No. : 14362-31-3

MCE 站：Chlorcyclizine hydrochloride

产品活性：Chlorcyclizine hydrochloride 是一种组胺 H1 拮抗剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vivo: Pregnant rats administered 30, 60, ａnd 90mg/kg Chlorcyclizine during the sensitive period for palate development survived until scheduled sacrifice on Gestation Days (GDs) 17 or 21. The rats administered 60 or 90mg/kg Chlorcyclizine have transient adverse clinical signs (chromorhinorrhea, red peri-oral substance, urogenital staining, ａnd scant stool) ａnd a concomitant body weight loss of 7% ａnd 11%, respectively, over the dosing interval. Rats administered 30mg/kg Chlorcyclizine do not exhibit any adverse clinical signs, but do not gain weight over the dose interval as would be expected during pregnancy. Based on the testing facility’s historical control database (16 studies, n=380). pregnant rats typically gain about 6% body weight from GDs 12 to 15.

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