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L-Ascorbic acid 2-phosphate trisodium

CAS No. : 66170-10-3

MCE 站：L-Ascorbic acid 2-phosphate trisodium

产品活性：L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) 是一种长效的维生素 C 衍生物 (vitamin C derivative)，可以刺激胶原蛋白的表达和形成。L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) 可以作为培养基补充人脂肪干细胞 (hASCs) 的成骨分化。L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) 增加成骨细胞分化过程中 hASC 中的碱性磷酸酶 (ALP) 活性和 runx2A 的表达。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Phosphatase  |  Reactive Oxygen Species  |  Endogenous Metabolite

In Vitro: L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) trisodium significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect .
L-Ascorbic acid 2-phosphate (50 ?M-250 ?M) trisodium is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 ?M AsA2-P and 10 nM dexamethasone (Dex), and 250 ?M AsA2-P and 5 nM Dex.

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