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12-HETE

CAS No. : 71030-37-0

MCE 站：12-HETE

产品活性：12-HETE 是花生四烯酸在 12-LOX 催化下的主要代谢产物，抑制细胞凋亡。12-HETE 通过整合素连接激酶 (ILK) 通路促进 NF-κB 的活化和核转位。12-HETE 具有抗血栓形成和促血栓形成作用。12-HETE 还是一种神经调节剂。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: 12-HETE participates in the inhibition of cell apoptosis by activating the ILK/NF-κB pathway, implying an important underlying mechanism that promotes the survival of ovarian cancer cells. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. 12-HETE protects against cell apoptosis in ovarian cancer cells in a concentration-dependent manner. 12-HETE (1 ?M) significantly decreases the activation of caspase-3 induced by serum deprivation (SD).12-HETE represses the increased activity of caspase-3 induced by SD in a concentration-dependent manner, with an IC₅₀ value of 1.13 ?M.
12-HETE (1 ?M) facilitates the activation and nuclear translocation of NF-κB via ILK in ovarian cancer cells.
12-HETE inhibits insulin secretion, reduces metabolic activity and induces cell death in human islets. 12-HETE increases bovine platelet aggregation induced by thrombin and inhibits prostaglandin E1-induced elevation of intracellular cAMP levels. 12-HETE inhibits washed platelet (WP) aggregation.
The neuronal effects of 12-HETE include attenuation of calcium influx and glutamate release as well as inhibition of AMPA receptor (AMPA-R) activation.

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