MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Farudodstat

CAS No. : 1035688-66-4

MCE 站：Farudodstat

产品活性：Farudodstat (ASLAN003) 是一种具有口服活性，有效的二氢乳清酸脱氢酶 (DHODH) 抑制剂，对人 DHODH 酶的 IC₅₀ 为 35 nM。Farudodstat 通过激活 AP-1 转录因子来抑制蛋白质合成。Farudodstat 可以诱导凋亡 (apoptosis)，并在急性髓样白血病 (AML) 异种移植小鼠中大大延长其生存期。

研究领域：Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Dihydroorotate Dehydrogenase  |  DNA/RNA Synthesis  |  Apoptosis

In Vitro: Farudodstat (0.01-100 μM; for 48 hours) inhibits leukemic cell proliferation. The cell viability is maintained at ~50% at Farudodstat 1 μM and higher.
Farudodstat (0.5, 1 μM; for 48 hours) significantly increases cleaved caspase 8.
Farudodstat (2, 4 μM; for 96 hours) decreases viability and induces differentiation in primary acute myeloid leukemia blasts and myelodysplastic syndrome samples.
Farudodstat (1, 2 μM; pretreatment 1 h before OPP for 1 h) inhibits protein synthesis, as demonstrated by the reduced incorporation of O-propargyl-puromycin (OPP) at protein translation sites in both MOLM-14 and KG-1 cells. Farudodstat causes the downregulation of EIF4B, and RPL6 proteins.

In Vivo: Farudodstat (50 mg/kg; oral gavage; once daily; from the day 3 to 30) substantially reduces the number of disseminated tumors and prolongs survival.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Ferroptosis Compound Library  |  Anti-COVID-19 Compound Library  |  Orally Active Compound Library  |  Anti-Blood Cancer Compound Library  |  Mitochondria-Targeted Compound Library  |  Transcription Factor Targeted Library  |  MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Y-27632 dihydrochloride  |  Paclitaxel  |  Cycloheximide  |  Angiotensin II human  |  Acetylcysteine  |  Staurosporine  |  Tamoxifen  |  5-Fluorouracil  |  Bortezomib  |  Sorafenib  |  2-Deoxy-D-glucose  |  Trametinib  |  Remdesivir  |  SP600125  |  Oxaliplatin  |  Gemcitabine  |  Temozolomide  |  MK-2206 dihydrochloride  |  Verteporfin  |  Decitabine  |  Etoposide  |  CCCP  |  Actinomycin D  |  DAPT  |  Pexidartinib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。