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Witha

CAS No. : 27570-38-3

MCE 站：Witha

产品活性：Witha 是来自 Withania somnifera 根的活性成分，在减轻认知功能障碍方面具有多功能的神经保护作用。在神经元样细胞中，Witha 可以抑制 NMDA 诱导的兴奋性毒性。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: Witha (5-20 μM; Neuro2a cells) treatment significantly reverses the cell death induced by NMDA in N2a cells.
Witha (5-20 μM; Neuro2a cells) treatment significantly normalizes Bax and Bcl-2 levels.
Attenuation of NMDA-induced intracellular calcium releases by Witha in N2a cells.
Witha attenuates NMDA-induced Reactive Oxygen Species generation in N2a cells and induces attenuation of mitochondrial membrane motential loss.
Witha treatment down-regulates the expression of cytochrome c.
Witha treatment decteases the Malondialdehyde levels in NMDA-induced excitotoxicity.
Witha shows promise in Alzheimer's disease (AD) treatment because of cognitive benefits and more importantly, mechanisms of action with respect to the fundamental pathophysiology of the disease, not limited to the inhibition of AChE, but also include the modification of Aβ processing, protection against oxidative stress and anti-inflammatory effects. Witha (24 hours) treatment shows significant protective effect against amyloid β (Aβ) toxicity in Aβ induced toxicity in PC-12 cells.

In Vivo: Witha (5-20 mg/kg; oral administration; daily; for 21 days; male Wistar rats) treatment shows significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuates the elevated levels of pro-inflammatory cytokines like TNF α, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Administration of Witha also significantly reverses the decline in acetyl choline and Glutathione (GSH) activity.

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