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Otenaproxesul

CAS No. : 1226895-20-0

MCE 站：Otenaproxesul

产品活性：Otenaproxesul (ATB-346) 是具有口服活性的、非甾体抗炎药(NSAID)，可抑制环氧合酶-1 和 2 (COX-1，2)。Otenaproxesul 具有抗炎生物活性，可用于缓解疼痛的研究。

研究领域：Immunology/Inflammation  |  Apoptosis

作用靶点：COX  |  Apoptosis

In Vitro: Otenaproxesul (100 μM) inhibits human melanoma cell proliferation by inhibiting pro-survival pathways associated with NF-B and Akt activation.
Otenaproxesul (100 μM) induces apoptosis of human melanoma cells.
Otenaproxesul (100 M) causes inhibition of IkB degradation and of NF-kB nuclear translocation as demonstrated by a reduction in band intensity of the p65 subunit in A375 cells.

In Vivo: Otenaproxesul exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity.
Otenaproxesul (orally, 43 μmol/kg) inhibits growth of melanoma tumors in vivo and reduce plasma levels of melanoma-associated chemokines.
Otenaproxesul (orally, 16 mg/kg) results in significant inhibition of bone defect and other histological characteristics (such as flatness of the gingival epithelium, chronic inflammatory cell infiltration and loss of connective tissue in the gingival papillae). Otenaproxesul inhibits the increase of gingival IL-1β and IL-6 secondary to periodontitis, but IL-10 is unaffected.

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