MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Chlorpromazine hydrochloride

CAS No. : 69-09-0

MCE 站：Chlorpromazine hydrochloride

产品活性：Chlorpromazine hydrochloride 是 D2，5HT2A，钾通道和钠通道的拮抗剂。Chlorpromazine Hydrochloride 与 D2 和 5HT2A 结合的 K_i 分别为 363 nM 和 8.3 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel  |  Autophagy

作用靶点：Dopamine Receptor  |  5-HT Receptor  |  Sodium Channel  |  Potassium Channel  |  Autophagy

In Vitro: Chlorpromazine (3, 10, 20, 40, and 60 μM) decreases the peak currents of hNav1.7 in a concentration-dependent manner, with IC₅₀ of 25.9 μM with a Hill coefficient of 2.3. Chlorpromazine (25 μM) produces strong use-dependent inhibition of the hNav1.7 current. Chlorpromazine blocks the hNav1.7 channel, independent of calmodulin. Chlorpromazine blocks HERG potassium channels with an IC₅₀ value of 21.6 μM and a Hill coefficient of 1.11. Chlorpromazine (1, 10, 100 μM) blocks HERG potassium channels expressed in Xenopus laevis oocytes in a concentration-dependent manner. Chlorpromazine blocks HERG potassium channels in the activated state.

In Vivo: Chlorpromazine (2 mg/kg, i.p.)-induced neurobehavioural abnormalities (NAs) are characterized by significant increase in cataleptic behaviour and loared spontaneous activity reaction time in mice. Chlorpromazine (1 or 5 mg/kg, i,p.) prevents KET from increasing average spectral power of delta and gamma-high bands on the 5th and 10th days of treatment in rats.

相关产品：Nigericin sodium salt  |  Clozapine N-oxide  |  MPTP hydrochloride  |  BAPTA-AM  |  EIPA  |  Amiloride hydrochloride  |  Oxidopamine hydrobromide  |  Branaplam  |  Monensin sodium salt  |  Serotonin hydrochloride  |  Harmine  |  Rosuvastatin Calcium  |  L-DOPA  |  Puerarin  |  Carbamazepine  |  Glibenclamide  |  Tetrandrine  |  Halofugi  |  Bromocriptine mesylate  |  Pimozide  |  SKF-96365 hydrochloride  |  SCH-23390 hydrochloride  |  Amiodarone hydrochloride  |  Riluzole  |  PAP-1  |  5-(N,N-Hexamethylene)-amiloride  |  DCPIB  |  Haloperidol

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。