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PHA 568487 free base

CAS No. : 527680-56-4

MCE 站：PHA 568487 free base

产品活性：PHA 568487 free base 是一种选择性的 α 7 烟碱乙酰胆碱受体 (α-7 nAchR) 激动剂。PHA 568487 free base 可用于减缓神经炎症。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：nAChR

In Vitro: PHA 568487, α-7 nAchR-specific agonist, prevents NF-κb activation in the cells.
PHA 568487 treatment significantly reduces the expression of leukocyte infiltration molecules in MCAO rats ａnd in endothelial cells after in vitro ischemia.

In Vivo: PHA 568487 treatment reduces mouse cognitive decline caused by aseptic bone fracture by promoting inflammation resolution. PHA 568487 (PHA; 0.8 mg/kg; injected intraperitoneally) reduces infarct volume ａnd TUNEL positive neurons in the peri-infarct regions of permanent middle cerebral artery occlusion (pMCAO) ａnd pMCAO+tibia fracture mice.
The role played by a7 receptors on neuroinflammation is supported by the decrease of [¹⁸F]DPA-714 binding in ischemic rats treated with the a7 agonist PHA 568487 at day 7 after MCAO.
PHA 568487-treated ischemic rats show a significant reduction of the cerebral infarct volumes ａnd an improvement of the neurologic outcome compared with non-treated MCAO rats.

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