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Zeaxanthin dipalmitate

CAS No. : 144-67-2

MCE 站：Zeaxanthin dipalmitate

产品活性：Zeaxanthin dipalmitate (Physalien) 是一种枸杞衍生的类胡萝卜素，具有抗炎和抗氧化应激作用。Zeaxanthin dipalmitate 与 p2X7 受体 (K_d=81.2 nM) 和脂联素受体 1 (AdipoR1; K_d=533 nM) 以正剂量依赖性方式直接相互作用。Zeaxanthin dipalmitate 恢复乙醇中毒抑制的线粒体自噬 (autophagy) 功能。Zeaxanthin dipalmitate 可用于酒精性脂肪肝 (AFLD)、色素性视网膜炎 (RP) 的研究。

研究领域：GPCR/G Protein  |  Membrane Transporter/Ion Channel  |  Autophagy

作用靶点：Adiponectin Receptor  |  P2X Receptor  |  Autophagy

In Vitro: Zeaxanthin dipalmitate (1 M; 2 h) totally or partially reverses the down-regulation of Atg5, beclin-1, ａnd LC3A/B by ethanol (250 mM), ａnd the up-regulation of p62 by ethanol in BRL-3A cells.
Zeaxanthin dipalmitate (1 M; 2 h) partially recovers the ethanol-suppressed LC3B in BRL-3A cells.
Zeaxanthin dipalmitate (1 M; 2 h) partially recovers the ethanol-suppressed cell viability ａnd ethanol-induced aspase-3/7 activity of BRL-3A cells.
Zeaxanthin dipalmitate (1 M; 2 h) recovers the ethanol-induced inhibition of mitophagy in BRL-3A cells.

In Vivo: Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) reduces the serum ALT ａnd AST levels increased by long-term ethanol challenge in at AFLD Model.
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) effectively attenuates the histological injury.
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) attenuates the AFLD-induced hepatic apoptosis (reveal by caspase-3/7 activity) ａnd inflammation (TNF-α) in rat.
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the visual behavior of rd10 mice ａnd delays the degeneration of retinal photoreceptors.
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the light responses of photoreceptors, bipolar cells ａnd retinal ganglion cells.
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) reduces the expression of genes that are involved in inflammation, apoptosis ａnd oxidative stress in rd10 mice.

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