MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PrNMI

CAS No. : 1541244-33-0

MCE 站：PrNMI

产品活性：PrNMI 是一种有效的、具有口服活性的外周限制性大麻素 1 受体 (CB1R) 激动剂。PrNMI 可抑制化疗引起的周围神经病变疼痛症状，并且还可作为癌症引起的骨痛的镇痛剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Cannabinoid Receptor

In Vitro: PrNMI (1 nM-1 μM; 24 hours) shows no effects on viability of 66.1 breast tumor cells in vitro.

In Vivo: PrNMI (0.25 mg/kg; Intraplantar ipsilateral administration; i.p.) causes significantly greater suppression in mechanical but not cold allodynia on the ipsilateral paw compared to contralateral paw or systemic administration at 2 h post-PrNMI.
PrNMI (3.0 mg/kg; i.g.; 48 hours) dose-dependently suppresses CIPN symptoms in both male ａnd female rats ａnd is equally effective in male ａnd female rats after oral administration.
PrNMI (1 mg/kg; p.o.; 48 hours) exhibits anti-allodynic effects in CIPN mediated mainly by CB1Rs.
PrNMI (1 mg/kg; p.o.; daily for two weeks) shows no significant tolerance to suppression of both mechanical ａnd cold allodynia during the two-week testing period.
PrNMI (0.1, 0.3, ａnd 0.6 mg/kg; i.p.) results in a significant, time-related reduction of flinching but not guarding in a dose-dependent manner. This suppression of flinching starts 1-hour post-injection ａnd persists for at least 5 hours.

相关产品：Rimonabant Hydrochloride  |  WIN 55,212-2 Mesylate  |  AM251  |  JD-5037  |  SR144528  |  6-Iodopravadoline  |  Pregnenolone  |  2-Arachidonoylglycerol  |  Taranabant  |  Anandamide  |  β-Caryophyllene  |  Olorinab  |  Olivetol  |  GW842166X  |  N-Oleoyl glycine  |  Org 27569  |  TM38837  |  EHP-101  |  (±)-Ibipinabant  |  Bay 59-3074  |  MDA 19  |  LY2828360  |  BML-190  |  Otenabant  |  Yangonin  |  AM-6538  |  A-836339

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。