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Antitumor agent-37

CAS No. :

MCE 站：Antitumor agent-37

产品活性：Antitumor agent-37 具有有效的抗增殖和抗转移活性。Antitumor agent-37 诱导严重的 DNA 损伤并进一步导致 γ-H2AX 和 p53 的高表达。Antitumor agent-37通过线粒体凋亡通路 Bcl-2/Bax/caspase3 促进肿瘤细胞凋亡 (apoptosis)。Antitumor agent-37 通过抑制 PD-L1 的表达以增加肿瘤组织中 CD3+ 和 CD8+ T 浸润细胞显著改善免疫反应。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: Antitumor agent-37 (compound 7) (24-76 hours) displays relatively lower activities after 24 h treatment, ａnd the IC₅₀ values decreases at 48 h, ａnd the activities at 72 h are similar to that of 48 h.
Antitumor agent-37 (compound 7) (24 hours) induces significant apoptosis of tumor cells in a dose-dependent manner.
Antitumor agent-37 (compound 7) (24 hours) induces serious apoptosis of tumor cells by the activation of mitochondrial pathway Bcl-2/Bax/caspase3.

In Vivo: Antitumor agent-37 (compound 7) (i.p.; 4 mg Pt/kg; four times on days 3, 6, 9, ａnd 12 post-tumor inoculation) exerts no visible impacts on body weight of mice in comparison with the blank group, which is obviously superior to reference drug OLP ａnd complex 9, indicating its low toxicity in vivo.
Antitumor agent-37 (compound 7) (i.p.; 4 mg Pt/kg; four times on days 3, 6, 9, ａnd 12 post-tumor inoculation) also exhibits prominent tumor growth inhibition to 4T1 tumors with a TGI of 54.6%.
Antitumor agent-37 (compound 7) (i.p.; 2 mg Pt/kg; four times on days 2, 4, 6, 8, 10, 12, ａnd 14 post-tumor inoculation) displays significantly more effective antimetastasis effects than CDDP ａnd OLP in vivo.

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