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Antroquinonol

CAS No. : 1010081-09-0

MCE 站：Antroquinonol

产品活性：Antroquinonol ((+)-Antroquinonol) 是一种来源于 Antrodia camphorata 的泛醌衍生物，具有保肝、抗炎和抗癌作用。Antroquinonol 可用于结肠癌的研究。Antroquinonol 通过增强 Nrf2 信号通路降低氧化应激，抑制局灶节段性肾小球硬化小鼠的炎症和硬化。

研究领域：NF-κB

作用靶点：Keap1-Nrf2

In Vitro: Antroquinonol is a ubiqui derivative from A.camphorata.
Antroquinonol inhibits cell growth ａnd suppresses the migratory/invasive ability of human colon cancer cells. Antroquinonol at high concentrations (40-80 μM) exhibits growth inhibitory activities in the three colon cancer cell lines, whereas low concentrations of Antroquinonol (2.5-20 μM) shows modest growth inhibition.
Antroquinonol possesses the ability to inhibit breast cancer migration/invasion by inhibiting the EMT ａnd MMP-9 gene expression.
Antroquinonol has inducible nitric oxide synthase (iNOS) inhibitory activity in lipopolysaccharide (LPS)-activated macrophages, anti-inflammatory activity in macrophage cell cultures by reducing the production of tumor necrosis factor-α ａnd interleukin (IL)-1β, ａnd anti-cancer activity against hepatoma cells.

In Vivo: Antroquinonol is a major active component of a mushroom, namely Antrodia camphorate, ａnd it has inhibitory effects on nitric oxide production ａnd inflammatory reactions.Antroq ameliorates proteinuria, improves renal function, ａnd decreases renal lesions, including EPHL, a severe index of glomerular injury, in FSGS mice.

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