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KF38789

CAS No. : 257292-29-8

MCE 站：KF38789

产品活性：KF38789 选择性抑制 P-selectin 与 PSGL-1 结合。KF38789 抑制 U937 细胞与 P-selectin 免疫球蛋白 G 嵌合蛋白 (P-selectin-Ig) 结合，IC₅₀ 值为 1.97 μM。

研究领域：Others

作用靶点：Others

In Vitro: KF38789 inhibits P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF38789 significantly inhibits the thioglycollate (TG)-induced accumulation of leukocytes in the mouse peritoneal cavity.
KF38789 displays a concentration-dependent inhibition of U937 cell adhesion to immobilized P-selectin-Ig with an IC₅₀ value of 1.97±0.74 μM.
KF38789 specifically inhibits P-selectin-dependent cell adhesion ａnd the leukocyte recruitment in mouse peritonitis.
KF38789 (5μM) significantly reduces closure of a 500-μm gap between confluent sheets of Human corneal epithelial (HCE)-T cells over an 8-hr period (by 40%).
Corneal epithelial cell migration is reduced in the presence of KF38789 (5μM) .

In Vivo: KF38789 can block P-selectin-mediated binding in vitro ａnd leukocyte accumulation in vivo.
Intraperitoneal injection of the P-selectin inhibitor KF38789 (daily intraperitoneal injection of 10mg/kg for 12 days) significantly reduces mechanical allodynia in the facial carrageenan-injected mice.

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