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Triheptanoin

CAS No. : 620-67-7

MCE 站：Triheptanoin

产品活性：Triheptanoin (Propane-1,2,3-triyl triheptanoate) 是一种合成的中链甘油三酯 (MCT)，由甘油主链上的三个奇数链 7-碳（庚酸）脂肪酸组成。可用于遗传代谢紊乱的研究。

研究领域：Others

作用靶点：Others

In Vivo: In long-chain fatty acid oxidation disorders (LC-FAOD), Triheptanoin is used as an anaplerotic compound, acting as a source of calories ａnd fatty acids to bypass the LC-FAOD enzyme deficiencies.
Triheptanoin can be used for the research of ataxia-telangiectasia (A-T).
Triheptanoin functions as an anaplerotic agent replenishing tricarboxylic acid (TCA) cycle intermediates by metabolism to heptanoate (C7) ａnd subsequently acetyl-CoA ａnd propionyl-CoA that feed into the TCA cycle to supply energy.
Triheptanoin mitigates brain ATP depletion ａnd mitochondrial dysfunction, including respiration ａnd redox balance in a mouse model of Alzheimer＇s disease, supporting the energy failure hypothesis for that disorder.
Triheptanoin (Mice were treated with Triheptanoin (35E%) for 10 days prior to pilocarpine injection to induce status epilepticus) preserved mitochondrial functions in the hippocampal formations of pilocarpine-induced status epilepticus (SE) mice.

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