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Clomipramine

CAS No. : 303-49-1

MCE 站：Clomipramine

产品活性：Clomipramine (Chlorimipramine) 有效阻断 5-HT 再摄取 (5-HT reuptake)，IC₅₀ 值为 1.5 nM。Clomipramine 是一种三环类抗抑郁药，可用于抑郁症和强迫症 (OCD) 的研究。

研究领域：Neuronal Signaling

作用靶点：Serotonin Transporter

In Vitro: Clomipramine can inhibit reuptake of both noradrenaline ａnd 5-HT, although Clomipramine inhibits 5-HT reuptake more strongly than it inhibits noradrenaline reuptake.
The antidepressant Clomipramine inhibits both venom AChE as well as human serum BChE in a concentration-dependent manner but has no effect on AChE in the rat brain striatum. Clomipramine interferes with the autophagic flux ａnd severely compromises the viability of tumorigenic cells upon cytotoxic stress.
Clomipramine reduces autophagy in neuronal primary cultures. Clomipramine (1 ａnd 5M) negatively regulates neuronal autophagic pathway in primary cultured cells.

In Vivo: Clomipramine (5-20 mg/kg; i.p) elicits significant hyperglycemia in mice. Clomipramine induces hyperglycemia in mice by blocking the 5-HT2B and/or 5-HT2C receptors, which results in facilitation of adrenaline release. In mice, Clomipramine reduces immobility in the forced swimming test, which is the behavioral model for antidepressants. Clomipramine also inhibits the OCD animal model, marble burying behavior in mice. Clomipramine (20mg/kg) decreases autophagic flux in murine tissues.

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