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Taurochenodeoxycholic acid sodium

CAS No. : 6009-98-9

MCE 站：Taurochenodeoxycholic acid sodium

产品活性：Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium 是动物胆汁酸的主要生物活性物质。Taurochenodeoxycholic acid sodium 可诱导细胞凋亡 (apoptosis)，并具有明显的抗炎和免疫调节作用。

研究领域：Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Endogenous Metabolite

In Vitro: Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid sodium significantly augments PKC mRNA levels, activities ａnd increases JNK, caspase-3 ａnd caspase-8 mRNA expression levels, activities.

In Vivo: Taurochenodeoxycholic acid (12-Deoxycholyltaurine; TCDCA; 0.05, 0.1g/kg) sodium decreases the pulmonary coefficient in the model mice ａnd reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α ａnd TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice ａnd has no significant effects on MMP2.
Taurochenodeoxycholic acid sodium significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids ａnd hydrophobicity index, ａnd tended to attenuate the intestinal inflammation.
Taurochenodeoxycholic acid sodium significantly suppresses paw swelling ａnd polyarthritis index, increases the loss body weight ａnd index of thymus ａnd spleen, ａnd amends radiologic changes in AA rats. The overproduction ａnd mRNA expression of TNF-α, IL-1β ａnd IL-6 are remarkably suppressed in serum ａnd synovium tissue of all TCDCA-treated rats.

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