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Norepinephrine tartrate

CAS No. : 51-40-1

MCE 站：Norepinephrine tartrate

产品活性：Norepinephrine (Levarterenol; L-Noradrenaline) tartrate 是一种有效的肾上腺素能受体 (AR) 激动剂。Norepinephrine tartrate 可以激活 α₁、α₂、β₁ 受体。

研究领域：Metabolic Enzyme/Protease  |  Neuronal Signaling  |  GPCR/G Protein  |  Autophagy

作用靶点：Endogenous Metabolite  |  Adrenergic Receptor  |  Autophagy

In Vitro: Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β₁-subtype selective adrenergic agonist over β₂-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β₂-adrenoceptor in higher concentrations.
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice ａnd cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 M) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, ａnd CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, ａnd liberated fatty acids are required to functionally activate UCP1 protein ａnd to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment ａnd significantly attenuated with CGP co-treatment in mouse iWA.

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