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Anti-Liver Cancer Compound Library
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Anti-Liver Cancer Compound Library
MCE 站:Anti-Liver Cancer Compound Library
Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc. MCE offers a unique collection of 1305 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.
Description & Advantages:
A unique collection of 1305 compounds with identified and potential anti-liver cancer activity for high throughput screening (HTS) and high content screening (HCS).
A useful tool for the discovery of anti-liver cancer drugs.
Target diverse, medicinally active and cell permeable.
Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
More detailed compound information with structure, IC50, and other chemical & biological data.
High purity and quality validated by NMR and LC/MS.
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