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HDAC-IN-9

CAS No. :

MCE 站：HDAC-IN-9

产品活性：HDAC-IN-9 是一种有效的选择性 tubulin 和 HDAC 双重抑制剂。HDAC-IN-9 抑制 A549 细胞的侵袭和迁移。HDAC-IN-9 在体外和体内均显示出有效的抗肿瘤和抗血管生成作用。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Cytoskeleton  |  Apoptosis

作用靶点：HDAC  |  Microtubule/Tubulin  |  Apoptosis

In Vitro: HDAC-IN-9 (compound 4s) shows anti-proliferative activity (IC₅₀s of 1.821, 2.538, 4.84, 1.782, 2.525, 0.371 M for MCF-7, MGC-803, HeLa, A549, HepG2, U937 cells, respectively).
HDAC-IN-9 displays 6.1, 3.2 ａnd 4.6-fold selectivity ratios for 293 T, macrophages, ａnd L02 cells respectively (IC₅₀s of 10.89, 5.63, 8.14 M for 293 T, macrophages, ａnd L02 cells, respectively).
HDAC-IN-9 shows inhibition activities against HDAC isoforms (IC₅₀s of 6.8, 0.06, 0.12, 8.5 M for HDAC 1, HDAC 2, HDAC 6, HDAC 10, respectively).
HDAC-IN-9 (1, 2, 4 M; 72 h; A459 cells) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner.
HDAC-IN-9 (1, 2, 4 M; 72 h) induces apoptosis via a Caspase-dependent intrinsic mitochondrial-mediated pathway in A549 cells.
HDAC-IN-9 (0, 0.5, 1, 2 M; 48 h) shows anti-proliferative activity by the inhibition of angiogenesis ａnd the reduction of endothelial cell metastasis in A549 cells.
HDAC-IN-9 (0, 1, 2, 4 M, 48 h) inhibits the invasion ａnd migration of A549 cells.

In Vivo: HDAC-IN-9 (0, 10, 20, 40 M) suppresses the formation of intersegmental blood vessels (ISVs) in zebrafish embryos.
HDAC-IN-9 (0, 2.5, 5, 10 M; 3 days) inhibits the proliferation ａnd metastasis of A549 cells in zebrafish xenograft models.

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