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Erucin

CAS No. : 4430-36-8

MCE 站：Erucin

产品活性：Erucin (ERU) 是一种异硫氰酸盐 (isothiocyanate)，在芝麻菜 (arugula) 中尤其丰富。Erucin 具有抗癌 (anticancer)、神经保护和抗炎活性。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: Erucin (ERU) (0-100 μM) releases H₂S ａnd inhibits cell viability in AsPC1 cells in a concentration-dependent manner.
Erucin inhibits cell migration ａnd altered the AsPC1 cell cycle, reducing G0/G1 phase ａnd increasing G2/M ａnd S phases.
Erucin (30 μM, 72 h) induces AsPC1 cell apoptosis ａnd inhibits cell migration.
Erucin reduces levels of phosphorylated ERK1/2 in AsPC1 cells.
Erucin (0-200 μM, 24 h) shows antiproliferative activity with an IC₅₀ of 97.7 M in A549 cells.
Erucin (0-50 μM, 24 h) induces the cleavage of PARP-1 at 50 M, ａnd increases p53 ａnd p21 protein expression in A549 cells.
Erucin decreases LPS-induced production of NO, prostaglandin E₂ (PGE₂), TNF-α, IL-6 ａnd IL-1β in RAW 264.7 cells.
Erucin decreases LPS-induced expression of inducible nitric oxide synthase (iNOS) ａnd cyclooxygenase (COX)-2 in RAW 264.7 cells.
Erucin inhibits LPS-induced activation of NFκB Signaling in RAW 264.7 cells.

In Vivo: Erucin (ERU) (0-300 nM) significantly inhibits TPA-induced edema formation.Erucin (30 μmol/kg; i.p.; twice a week for 4 week) shows neuroprotective effects.

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