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Anti-diabetic Compound Library

MCE 站：Anti-diabetic Compound Library

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I ａnd Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas ａnd insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion ａnd relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body ａnd can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss ａnd nerve damage. The pathogenesis of diabetes is complicated, ａnd development of the safe ａnd effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation ａnd chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases ａnd diabetes.MCE Anti-diabetic Compound Library owns a unique collection of 552 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Description & Advantages:

   A unique collection of 552 anti-diabetic compounds.

   The major targets include SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc.

   A useful tool for the discovery of anti-diabetic drugs.

   More detailed compound information with structure, IC₅₀, ａnd other chemical & biological data.

   NMR ａnd HPLC validated ensure high purity.

   All compounds are in stock ａnd continuously updated.

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