MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

A 83-01 sodium

CAS No. :

MCE 站：A 83-01 sodium

产品活性：A 83-01 sodium 是一种有效的 TGF-β I 型受体 ALK5，ALK4 和 ALK7 的抑制剂，能够抑制 ALK5，ALK4 和 ALK7 诱导的转录，IC₅₀ 值分别为 12 nM，45 nM 和 7.5 nM。

研究领域：TGF-beta/Smad

作用靶点：TGF-β Receptor

In Vitro: A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 ａnd type I nodal receptor ALK7, reduces the level of ALK-5-induced transcription with an IC₅₀ of 12 nM in Mv1Lu cells, also blocks the ALK4-TD ａnd ALK7-TD induced transcription with IC₅₀s of 45 nM ａnd 7.5 nM in R4-2 cells, ａnd weakly suppresses that induced by constitutively active ALK-6, ALK-2, ALK-3, ａnd ALK-1. A 83-01 (0.03-10 M) potently prevents the growth-inhibitory effects of TGF-β, ａnd completely inhibits the effect at 3 M. A 83-01 (1-10 M) inhibits TGF-β-induced Smad activation in HaCaT cells. A 83-01 (1 M) decreases cell motility, adhesion ａnd invasion increased by TGF-β1 in HM-1 cells, but does not change cell proliferation.

In Vivo: A 83-01 (50, 150 ａnd 500 μg/mouse, i.p.) sodium significantly improves survival of the mice without body weight or neurobehavioral appearances. A 83-01 (0.5 mg/kg, i.p.) sodium shows a significantly strong antitumor effect in mice bearing M109 cells.

相关产品：Bioactive Compound Library Plus  |  Dorsomorphin  |  SB-431542  |  A 83-01  |  Galunisertib  |  LDN193189  |  RepSox  |  LY2109761  |  SB 525334  |  DMH-1  |  Vactosertib  |  BMP signaling agonist sb4  |  LY-364947  |  SB-505124  |  LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)  |  GW788388  |  LY3200882  |  ITD-1  |  PF-06952229  |  SD-208  |  K02288  |  LDN-212854  |  SJ000291942  |  ML347  |  LDN-214117  |  R-268712  |  AZ12601011  |  IN-1130

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。