MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

H3R antagonist 1 hydrochloride

CAS No. :

MCE 站：H3R antagonist 1 hydrochloride

产品活性：H3R antagonist 1 hydrochloride 是一种有效的组胺受体 3 (H3R) 反向激动剂，详细信息请参考文献 WO2013107336A1 中的化合物 2。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Treatment with H3R antagonist 1 hydrochloride, which is a H3R inverse agonist, promotes oligodendrocyte precursor cell (OPC) differentiation in a dose-dependent manner, at EC₅₀=25 nM. Western blot reveals a significant increase in expression levels of two markers of mature oligodendrocytes, myelin-associated glycoprotein (MAG) ａnd myeline basic protein (MBP) in differentiating oligodendrocytes after treatment with H3R antagonist 1 hydrochloride, which suggests that treatment with H3R antagonist 1 hydrochloride drives more OPCs to differentiate. H3R antagonist 1 hydrochloride increases the Forskolin-stimulated cAMP level in the primary oligodendrocyte precursor cells in a dose-dependent manner.

In Vivo: The ability of H3R antagonist 1 hydrochloride-1 to enhance in vivo remyelination is determined with the Cuprizone/Rapamycin-induced demyelination model. Mice are treated with Cuprizone diet combined with intraperitoneal injections of Rapamycin for 5 weeks followed by 9 days of compound administration. Cuprizone diet plus intraperitoneal injections of Rapamycin induced severe demyelination in both corpus callosum ａnd cortex ａnd treatment with H3R antagonist 1 hydrochloride (30 mg/kg, 9 days) significantly increases density of myelin specific Black-gold II staining in the lesion of corpus callosum ａnd cortex in forebrain, compared to vehicle control group.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Neuronal Signaling Compound Library  |  Endocrinology Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Parkinson＇s Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Anti-Obesity Compound Library  |  Histamine  |  Terfenadine  |  Clemastine fumarate  |  Osthole  |  Astemizole  |  Amitriptyline hydrochloride  |  Fexofenadine hydrochloride  |  Levocetirizine dihydrochloride  |  Diphenhydramine hydrochloride  |  Loratadine  |  Perphenazine  |  Cimetidine  |  Famotidine  |  Chlorpheniramine maleate  |  Desloratadine  |  Rupatadine Fumarate  |  Promethazine hydrochloride  |  Ritanserin  |  Hydroxyzine dihydrochloride  |  Doxepin Hydrochloride  |  Mianserin hydrochloride  |  Chlorprothixene  |  Ebastine  |  Pitolisant hydrochloride  |  Azelastine hydrochloride  |  Latrepirdine dihydrochloride  |  Lodoxamide  |  Ranitidine hydrochloride  |  Cinnarizine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。