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Nuclear Receptor Compound Library

MCE 站：Nuclear Receptor Compound Library

Nuclear receptors (NR) are proteins found in cells that sense androgen ａnd thyroid hormones ａnd certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology ａnd pathology, ａnd regulate the expression of various important genes. Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders ａnd diabetes. 13% of U.S. Food ａnd Drug Administration (FDA) approved drugs target nuclear receptors. MCE supplies a unique collection of 520 nuclear receptor inhibitors ａnd activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease ａnd diabetes.

Description & Advantages:

    A unique collection of 520 nuclear receptor inhibitors ａnd activators for high throughput screening (HTS) ａnd high content screening (HCS).

    A useful tool for studying the relationship between diseases ａnd nuclear receptor.

   Target diverse, medicinally active ａnd cell permeable.

   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some have been approved by FDA.

   More detailed compound information with structure, IC50, ａnd other chemical & biological data.

   High purity ａnd quality validated by NMR ａnd LC/MS.

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