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Target Protein Ligand Library

MCE 站：Target Protein Ligand Library

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker ａnd a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, ａnd BCR-ABL to overcome resistance. MCE carefully prepared a unique collection of 28 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

Description & Advantages:

   A unique collection of 28 ligands for target protein of PROTAC, which can be used for PROTAC design.

   A useful tool for PROTAC development.

   Mainly target AR, ER, BTK, BET, ａnd BCR-ABL.

   More detailed compound information with structure, IC50, ａnd brief introduction.

   High purity ａnd quality validated by NMR ａnd LC/MS.

   All compounds are in stock ａnd continuously updated.

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