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Tivozanib hydrochloride hydrate
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Tivozanib hydrochloride hydrate
CAS No. : 682745-41-1
MCE 站:Tivozanib hydrochloride hydrate
产品活性:Tivozanib hydrochloride hydrate 是一种有效的、选择性的、具有口服活性的 VEGFR 酪氨酸激酶 抑制剂,对 VEGFR-1、VEGFR-2、VEGFR-3的 IC50 值分别为 0.21、0.16、0.24 nM。Tivozanib hydrochloride hydrate 抑制肿瘤组织中的血管生成和血管通透性,并显示出抗肿瘤活性。Tivozanib hydrochloride hydrate 具有研究转移性肾细胞癌 (RCC) 的潜力。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:VEGFR
In Vitro: Tivozanib hydrochloride hydrate inhibits the phosphorylation of VEGFR-1, VEGFR-2 and VEGFR-3.
In Vivo: Tivozanib hydrochloride hydrate (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%.
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