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Gentamicin

CAS No. : 1403-66-3

MCE 站：Gentamicin

产品活性：Gentamicin 是一种具有口服活性的氨基糖苷类抗生素，抑制革兰氏阳性菌和革兰氏阴性细菌的生长并可抑制组织培养中的多种支原体菌株。Gentamicin 抑制 DNase I 活性的 IC₅₀ 值为 0.57 mM。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Bacterial

In Vitro: Gentamicin is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, ａnd does not inhibit virus replication.
Gentamicin has been used with success as an additive in commercial mycology media to inhibit growth of bacteria ａnd has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., ａnd Streptococcus faecalis) than penicillin ａnd streptomycin.
Gentamicin does not interfere with the production of cytopathic effect by certain echoviruses ａnd polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, ａnd human amnion cells, ａnd is stable at autoclave temperatures.
Gentamicin is produced by various species of the genus Micromonospora.
Gentamicin C1a binds in the major groove of the A-site of the RNA.

In Vivo: Gentamicin (oral ａnd injectable forms) exhibits effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model.
Gentamicin (0.27 g/kg) shows a significant reduction of bacteria on the foreign body in mouse.

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