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Mycophenolic acid sodium

CAS No. : 37415-62-6

MCE 站：Mycophenolic acid sodium

产品活性：Mycophenolic acid sodium 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂，EC₅₀ 为 0.24 M。Mycophenolic acid sodium 对多种 RNA 病毒具有抗病毒作用，包括流感 (influenza)。Mycophenolic acid sodium 是一种免疫抑制剂。具有抗血管生成和抗肿瘤作用。

研究领域：Apoptosis  |  Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Bacterial  |  Fungal  |  Antibiotic  |  Endogenous Metabolite

In Vitro: Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, ａnd hantavirus.
IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides.
Mycophenolic acid (0.01-1 μM; 72 hours) sodium exhibits preferential antiproliferative activity against the endothelial cells ａnd fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC₅₀ <500 nM for antimitotic effects.
Fibroblasts are also prone to Mycophenolic acid-induced cell cycle inhibition but exhibit a higher IC₅₀ (<1 μM) compared with endothelial cells. The two human tumor cell lines A549 non-small cell lung cancer cells ａnd PC3 prostate cancer cells show intermediate sensitivity with an IC₅₀ >1 μM. U87 glioblastoma cells are resistant against Mycophenolic acid sodium treatment up to 1 μM.
Mycophenolic acid (0.05-2 μM; 18 hours) sodium exhibits a dose-dependent down-regulation of HDAC2 ａnd MYC, whereas up-regulates NDRG1.

In Vivo: Mycophenolic acid (120 mg/kg; oral gavage; b.i.d.) sodium exerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice.

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