MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Pentamidine dimesylate

CAS No. : 6823-79-6

MCE 站：Pentamidine dimesylate

产品活性：Pentamidine (MP-601205) dimesylate 是一种抗微生物剂，会干扰 DNA 的生物合成。Pentamidine dimesylate 抑制寄生虫 Leishmania infantum，IC₅₀ 为 2.5 μM。Pentamidine dimesylate 是一种有效的选择性蛋白酪氨酸磷酸酶 (PTPases) 和再生肝磷酸酶 (PRL) 抑制剂。Pentamidine dimesylate 可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究。抗肿瘤活性，抗菌活性。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Antibiotic  |  Parasite  |  Fungal  |  Phosphatase  |  Bacterial

In Vitro: Pentamidine (0-10 g/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, ａnd A549 cells) dimesylate treatment inhibits the growth of cancer cells in a concentration-dependent manner.
The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite Leishmania infantum is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis ａnd cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B－－>A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein.

In Vivo: Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) dimesylate treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice.

相关产品：Rapamycin  |  Ferrostatin-1  |  Chloroquine  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Puromycin dihydrochloride  |  Dexamethasone  |  Cycloheximide  |  Staurosporine  |  G-418 disulfate  |  Cyclosporin A  |  5-Azacytidine  |  Doxycycline (hyclate)  |  Etoposide  |  Nigericin sodium salt  |  CCCP  |  Brefeldin A  |  Actinomycin D  |  Resveratrol  |  Hygromycin B  |  Tunicamycin  |  Wortmannin  |  Bleomycin sulfate  |  Ionomycin  |  Tacrolimus  |  Dimethyl sulfoxide  |  Mitomycin C  |  Streptozocin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。