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Cimetidine hydrochloride
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Cimetidine hydrochloride
CAS No. : 70059-30-2
MCE 站:Cimetidine hydrochloride
产品活性:Cimetidine (SKF-92334) hydrochloride 是一种具有口服活性的,可逆的组胺 H2 受体拮抗剂,Ki 为 0.6 μM。Cimetidine hydrochloride 是一种胃酸减少剂,可用于十二指肠和胃溃疡研究。Cimetidine hydrochloride 具有抗癌和抗炎活性。
研究领域:GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation
作用靶点:Histamine Receptor
In Vitro: Cimetidine (SKF-92334) hydrochloride, a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers [1]. Cimetidine hydrochloride has no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells).
Cimetidine hydrochloride shows no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine hydrochloride reverses MDSC-mediated T-cell suppression, and improves IFN-γ production.
Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression.
In Vivo: Cimetidine (SKF-92334) hydrochloride reduces CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice.
Cimetidine hydrochloride exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption.
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热门标签:SKF-92334 hydrochloride