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Febuxostat sodium

CAS No. : 1140907-13-6

MCE 站：Febuxostat sodium

产品活性：Febuxostat (TEI 6720) sodium 是一种有效的、选择性的、非嘌呤 黄嘌呤氧化酶 (XO) 抑制剂，K_i 值为 0.6 nM。Febuxostat sodium 具有研究高尿酸血症和痛风的潜力。

研究领域：Metabolic Enzyme/Protease

作用靶点：Xanthine Oxidase

In Vitro: Febuxostat sodium displays potent mixed-type inhibition of the activity of purified bovine milk xanthine oxidase, with K_i ａnd K_i＇ values of 0.6 nM ａnd 3.1 nM respectively, indicating inhibition of both the oxidized ａnd reduced forms of xanthine oxidase.

In Vivo: Febuxostat sodium (5-6 mg/kg; i.e.; daily for 4 weeks) (fed a high-fructose diet (60% fructose) for 8 wk) significantly reduces lomerular pressure, renal vasoconstriction, ａnd afferent arteriolar area relative to fructose+P rats, ａnd shows no significant effects in rats on a normal diet when febuxostat treatment alone.
Febuxostat sodium (3-4 mg/kg; p.o.; daily for 4 weeks) with oxonic acid (750 mg/kg; oral gavage; daily for 4 weeks) preventes renal injury in 5/6 Nx (5/6 nephrectomy) rats with ａnd without coexisting hyperuricemia.
Febuxostat sodium (2.5 mg/kg; p.o.; daily for 12 weeks) inhibits plaque formation in ApoE/ mice ａnd reduces the levels of ROS in the aortic wall of atherosclerotic mice.
Febuxostat sodium (15.6 mg/kg; p.o.; once daily for 21 successive days) shows antidepressant effect by significantly reduces the immobility time in the FST in mouse.
Febuxostat sodium (10 mg/kg; p.o.; daily for 21 days) administration with doxorubicin caused a significant decrease in nephrotoxicity markers ａnd inflammatory mediators, restoration of normal values of oxidative stress biomarkers ａnd hampering the expression of renal caspase-3.

相关产品：Baicalein  |  Allopurinol  |  Febuxostat  |  Benzbromarone  |  Purpurogallin  |  Phytic acid  |  Lobetyolin  |  Oxypurinol  |  Topiroxostat  |  Allopurinol-d2  |  Benzbromarone-d5  |  Broussoflavonol F  |  Febuxostat-d7  |  Flazin  |  Forsythoside F  |  H-Tyr-Phe-OH  |  Ilexoside O  |  Morin 3-O-β-D-glucopyranoside  |  Myricetin 3-O-galactoside  |  Nequinate  |  O-Desisobutyl-O-n-propyl Febuxostat  |  Prudomestin  |  Tigulixostat  |  Topiroxostat-d4  |  Xanthine oxidase-IN-4  |  Xanthine oxidase-IN-5  |  Xanthine oxidase-IN-6

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