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Niraparib tosylate hydrate

CAS No. : 1613220-15-7

MCE 站：Niraparib tosylate hydrate

产品活性：Niraparib (MK-4827) tosylate hydrate 是高效的，具有生物口服利用度的 PARP1 和 PARP2 抑制剂，IC₅₀ 分别为 3.8 nM 和 2.1 nM。Niraparib tosylate hydrate 抑制 DNA 损伤修复，诱导凋亡 (apoptosis) 并具有抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Apoptosis

作用靶点：PARP  |  Apoptosis

In Vitro: Niraparib (MK-4827) tosylate hydrate inhibits PARP activity with EC₅₀=4 nM ａnd EC₉₀=45 nM in a whole cell assay. Niraparib tosylate hydrate inhibits proliferation of cancer cells with mutant BRCA-1 ａnd BRCA-2 with CC₅₀ in the 10-100 nM range. Niraparib tosylate hydrate displays excellent PARP 1 ａnd 2 inhibition with IC₅₀=3.8 ａnd 2.1 nM, respectively, ａnd in a whole cell assay.
Niraparib tosylate hydrate inhibits PARP within 15 minutes of treatment reaching about 85% inhibition in the A549 cells at 1 h ａnd about 55% inhibition at 1 h for the H1299 cells.

In Vivo: Niraparib (MK-4827) tosylate hydrate is well tolerated ａnd demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.
Niraparib (MK-4827) tosylate hydrate is well tolerated in vivo ａnd demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.
Niraparib (MK-4827) tosylate hydrate is characterized by acceptable pharmacokinetics in rats with plasma clearance of 28 (mL/min)/kg, very high volume of distribution (Vd_ss=6.9 L/kg), long terminal half-life (t_1/2=3.4 h), ａnd excellent bioavailability, F=65%.
Niraparib (MK-4827) tosylate hydrate enhances radiation response of p53 mutant Calu-6 tumor in both cases, with the single daily dose of 50 mg/kg being more effective than 25 mg/kg given twice daily.

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