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Pemirolast

CAS No. : 69372-19-6

MCE 站：Pemirolast

产品活性：Pemirolast 是一种具有口服活性的抗过敏试剂。Pemirolast 能够减轻紫杉醇处理导致的生物过敏反应，可用于对支气管哮喘和结膜炎的研究。

研究领域：Others

作用靶点：Others

In Vitro: Pemirolast (1 μM-1 mM) inhibits A23187-induced LTC4 ａnd ECP release from the eosinophils in a dose-dependent manner.
Pemirolast (0.1 mM ａnd 1 mM) also inhibits PAF-induced ａnd FMLP-induced ECP release from the eosinophils.
Pemirolast prevents the activation of human eosinophils to inhibit granule protein LTQ ａnd ECP release, so that alleviates controlling allergic diseases.
Pemirolast (100 nM-1 mM; 1-15 min) fails to significantly inhibit histamine release from human conjunctival mast cells.
Pemirolast (0.1 μg/mL-0.01 mg/mL) inhibits the activation of signal transduction phospholipases C ａnd AZ in rat peritoneal mast cells, by inhibiting the degranulation reaction of antigen ａnd compound 48/80, suppressing the formation of 1,2-diacylglycerol ａnd phosphatidylic acid.

In Vivo: Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats.
Pemirolast (0.1-1 mg/kg; i.v.) inhibits taxel-induced pulmonary vascular hyperpermeability, ａnd reverses paclitaxel-induced arterial PaO2 decreasing at a dosage of 1 mg/kg, 30 minutes after paclitaxel injection (15 mg/kg; i.v.).
Pemirolast (1 mg/kg; i.v.) reverses taxel-induced elevation of the concentrations of sensory neuropeptides (CGRP, substance P ａnd neurokinin A), 30 minutes after paclitaxel injection (15 mg/kg; i.v.).
Pemirolast (10 mg/kg/d; p.o.; 4-5 d) significantly reduces cisplatin-induced kaolin intake on days 3 ａnd 4 ａnd inhibits cisplatin-induced substance P release in the cerebrospinal fluid (CSF) in rats.

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