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Rosiglitazone potassium

CAS No. : 316371-84-3

MCE 站：Rosiglitazone potassium

产品活性：Rosiglitazone (BRL 49653) potassium 是一种具有口服活性的 PPARγ 选择性激动剂 (EC₅₀: 60 nM, K_d: 40 nM)。Rosiglitazone potassium 是一种 TRPC5 激活剂 (EC₅₀: 30 μM) 和 TRPM3 抑制剂。Rosiglitazone potassium 可用于肥胖、糖尿病、衰老、卵巢癌的研究。

研究领域：Cell Cycle/DNA Damage  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel  |  Autophagy  |  Apoptosis

作用靶点：PPAR  |  TRP Channel  |  Autophagy  |  Apoptosis  |  Ferroptosis

In Vitro: Rosiglitazone potassium (0.1-10 μM, 72 h) results in pluripotent C3H10T1/2 stem cell differentiation to adipocytes.
Rosiglitazone potassium (1 μM, 24 h) activates PPARγ, which binds to NF-α1 promoter to activate gene transcription in neurons.
Rosiglitazone potassium (1 μM, 24 h) protects Neuro2A cells ａnd hippocampal neurons against oxidative stress, ａnd up-regulates BCL-2 expression in an NF-α1-dependent manner.
Rosiglitazone potassium (0.01-100 μM, 15 min) inhibits TRPM3 with IC₅₀ values of 9.5 ａnd 4.6 μM against nifedipine- ａnd PregS-evoked activity respectively.
Rosiglitazone potassium (0.5-50 μM, 7 days) inhibits ovarian cancer cell proliferation.
Rosiglitazone potassium (5 μM, 7 days) suppresses Olaparib (HY-10162)induced alterations of cellular senescence ａnd promotes apoptosis in A2780 ａnd SKOV3 cells.

In Vivo: Rosiglitazone potassium (oral administration, 5 mg/kg, daily for 8 weeks) decreases the serum glucose in diabetic rats.
Rosiglitazone potassium (intraperitoneal injection, 3 mg/kg/day) ameliorates airway inflammation induced by cigarette smoke via inhibiting the M1 macrophage polarization by activating PPARγ ａnd RXRα in male Wistar rats.
Rosiglitazone potassium (intraperitoneal injection, 10 mg/kg, once every 2 days) inhibits subcutaneous ovarian cancer growth in A2780 ａnd SKOV3 mouse subcutaneous xenograft models.

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