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CD31 TFA

CAS No. :

MCE 站：CD31 TFA

产品活性：CD31 (PECAM-1) TFA 是血小板内皮细胞粘附分子 (platelet endothelial cell adhesion molecule-1)，是产气荚膜梭菌 b-Toxin (CPB) 的内皮细胞特异性受体。CD31 TFA 也是一种 ER-MP12 抗原，在机械应力、代谢和炎症之间起连接作用。CD31 TFA 肽能够维持 CD31 TFA ITIM₆₈₆ 和 SHP2 的磷酸化，并抑制 TCR 诱导的 T 细胞活化。

研究领域：Others

作用靶点：Others

In Vitro: CD31 TFA is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism ａnd inflammation.
CD31 TFA is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, ａnd producing signaling to up-regulation of other adhesion molecules in neighboring cells.
Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) ａnd the essential virulence factor for fatal, necro-hemorrhagic enteritis.
CD31 TFA serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 TFA directly interacts with CPB, with the membrane proximal Ig6 domain.
CD31 TFA also serves as a therapeutic target in atherosclerosis.
CD31 TFA (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner.

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