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Pectin

CAS No. : 9000-69-5

MCE 站：Pectin

产品活性：Pectin 是一种杂多糖，可从高等植物的细胞壁获得。Pectin 能够制成纳米颗粒，作为药物的运载载体。Pectin 也是一种吸附剂，一种广谱抗菌剂，可以结合肠道粘膜中的细菌毒素和其他刺激物，缓解受刺激的黏膜。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Endogenous Metabolite  |  Bacterial  |  Antibiotic

结构分类：糖类  |  多糖  |  其他类

来源：植物  |  蔷薇科  |  苹果

In Vitro: Pectin (5 mg/mL; 24, 48, ａnd 72 h) shows low cytotoxicity on HepG2 cells, ａnd can be made into nanoparticles (PPN), encapsulating Paclitaxel (HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h.
Pectin (3, 6 mg/mL; 48 h) inhibits Staphylococcus aureus ATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL.
Pectin inhibits Gram-negative Helicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL ａnd minimum bactericidal concentration (MBC) of 0.325 mg/mL.
Pectin displays lower antibacterial activity against E. coli with MICs of 25 mg/mL ａnd 50 mg/mL ａnd MBC values ranging between 25-50 mg/mL.
Pectin exhibits the antibacterial activity via its undissociated acid form.

In Vivo: Pectin serves as the nanoparticles encapsulating Paclitaxel (HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice.

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