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Chitosan

CAS No. : 9012-76-4

MCE 站：Chitosan

产品活性：Chitosan (Deacetylated chitin) 是衍生自几丁质的聚阳离子线性多糖。Chitosan 因其无毒，低致敏性，生物相容性和可生物降解性而被广泛使用。Chitosan 还具有抗肿瘤，抗细菌，抗真菌和抗氧化活性。

研究领域：Anti-infection

作用靶点：Bacterial  |  Fungal

结构分类：糖类  |  多糖  |  其他类

In Vitro: Chitosan (2 mg/mL; 48 hours; SKMEL28 ａnd RPMI7951 cells) treatment presents a reduced growth potential.
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment shows potent pro-apoptotic effects against RPMI7951 through the mitochondrial pathway.
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment induces an up regulation of pro-apoptotic molecules such as Bax ａnd a down regulation of anti-apoptotic proteins like Bcl-2 ａnd Bcl-XL.
Low-molecular-weight chitosan can penetrate bacterial cell walls, bind with DNA ａnd inhibit DNA transcription ａnd mRNA synthesis, while high-molecular-weight Chitosan can bind to the negatively charged components on the bacterial cell wall. It forms an impermeable layer around the cell, changes cell permeability ａnd blocks transport into the cell. Chitosan also can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity research ａnd as a scaffold for tissue engineering.

In Vivo: In chemical-induced colonic precancerous lesions in ICR mice, in the 2 weeks preventive experiments, mice fed with a diet containing high molecular weight Chitosan (HMWC) had significant fewer aberrant crypt foci formation than those fed with control diet. As the treatment extended to 6 weeks, both low molecular weight Chitosan (LMWC)- ａnd HMWC-fed mice contained less aberrant crypt foci when compared to control.

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