MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

N-Salicyloyltryptamine

CAS No. : 31384-98-2

MCE 站：N-Salicyloyltryptamine

产品活性：N-Salicyloyltryptamine 是一种电压依赖性离子通道抑制剂，包括 Na⁺、Ca²⁺、K⁺ 通道。N-Salicyloyltryptamine 抑制 K⁺ 电流的 IC₅₀ 为 34.6 μM (I_to)。N-Salicyloyltryptamine 还具有抗惊厥、抗炎、镇痛，和血管舒张的作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  MAPK/ERK Pathway  |  Stem Cell/Wnt  |  GPCR/G Protein  |  NF-κB

作用靶点：Calcium Channel  |  ERK  |  Potassium Channel  |  Guanylate Cyclase  |  NF-κB

In Vitro: N-Salicyloyltryptamine (1 ng/mL-1 μg/mL; 24 h) presents no cytotoxicity ａnd causes no oxidative stress in RAW 264.7 cells at low concentration, but (50 ａnd 100 μg/mL) inhibits cell viability with an IC₅₀ value of 22.75 μg/mL.
N-Salicyloyltryptamine (1 μg/mL; 24 h) reverses some redox ａnd inflammatory parameters induced by LPS without interfering in cell viability.
N-Salicyloyltryptamine (1 μg/mL; 24 h) inhibits LPS-induced TNF-α ａnd IL-1β release, as well as CD40 ａnd TNF-α protein up-regulation.
N-Salicyloyltryptamine (1 μg/mL; 24 h) inhibits phosphorylation of ERK 1/2 ａnd IκBα ａnd p65 nuclear translocation (NF-kB activation).
N-Salicyloyltryptamine (17 μM) inhibits K⁺ current by 59.27% (I_to) ａnd 73.18% (I_KD), inhibits L-type Ca²⁺ currents by 54.9%, ａnd shows few inhibition with high concentration (170 μM) on TTX-sensitive Na⁺ current by 22.1% in GH3 cells.
N-Salicyloyltryptamine (0.01 nM-100 M) produces vasorelaxation through activation of the NO/sGC/cGMP pathway ａnd reduction of calcium influx.

In Vivo: N-Salicyloyltryptamine (100 mg/kg; i.p.; 60 min before stimulation challenge) significantly inhibits pentylenetetrazol (PTZ)-induced seizures ａnd partially eliminates the extensor reflex of maximal electric-induced seizures test.
N-Salicyloyltryptamine (100 mg/kg, 200 mg/kg; i.p.; single dose) shows antinociceptive ａnd nerve excitability effects.

相关产品：Phorbol 12-myristate 13-acetate  |  Bortezomib  |  PD98059  |  Nigericin sodium salt  |  Ionomycin  |  Thapsigargin  |  L-Ascorbic acid  |  TBHQ  |  Yoda 1  |  TAK-243  |  SCH772984  |  Pyrrolidinedithiocarbamate ammonium  |  BAPTA-AM  |  JSH-23  |  Shikonin  |  Sulfasalazine  |  Minocycline hydrochloride  |  Triptolide  |  Aspirin  |  Dihydroartemisinin  |  Tauroursodeoxycholate  |  2-Aminoethyl diphenylborinate  |  Branaplam  |  Baicalin  |  Ravoxertinib  |  Acetylcholine chloride  |  Honokiol  |  Verapamil  |  Rocaglamide  |  BAY 11-7085

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。