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3＇,4＇-Dimethoxyflavone

CAS No. : 4143-62-8

MCE 站：3＇,4＇-Dimethoxyflavone

产品活性：3＇,4＇-Dimethoxyflavone 是一种亲脂性黄酮，可分离自黄花九轮草 (Primula veris) 的叶子。3＇,4＇-Dimethoxyflavone 可减少 PARP 的合成和积累，保护皮质神经元免受Parthanatos 通路诱导的细胞死亡。3＇,4＇-Dimethoxyflavone 在人乳腺癌细胞中也是一种芳香烃受体 (aryl hydrocarbon receptor) 拮抗剂。3＇,4＇-Dimethoxyflavone 能促进人体造血干细胞增殖。具有多种生物活性，包括抗氧化、抗癌、抗炎、抗动脉粥样硬化、降血脂和神经保护或神经营养作用。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：PARP  |  Reactive Oxygen Species  |  Aryl Hydrocarbon Receptor

In Vitro: 3＇,4＇-Dimethoxyflavone (10 ａnd 20 μM) has protection against the reduction in SH-SY5Y viability induced by Methylnitronitrosoguanidine (MNNG) (HY-128612).
3＇,4＇-Dimethoxyflavone (6.25-25 μM) decreases the levels of PAR induced by MNNG in HeLa cells.
3＇,4＇-Dimethoxyflavone (12.5, 25, 50 ａnd 100 μM; 15-20 h) reduces cortical neuronal death induced by exposure to NMDA (HY-17551).
3＇,4＇-Dimethoxyflavone (0.1-10 μM; 24 h) exhibits significant inhibition of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced EROD activity in MCF-7 ａnd T47D cells.
3＇,4＇-Dimethoxyflavone inhibits AhR-dependent CYP1A1 induction ａnd AhR-mediated inhibition of estrogen-induced gene expression in T47D ａnd MCF-7 breast cancer cells.
3′,4′-Dimethoxyflavone (2.5 μM; 7 days) promotes the proliferation of human hematopoietic stem cells.

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