MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ipratropium bromide hydrate

CAS No. : 66985-17-9

MCE 站：Ipratropium bromide hydrate

产品活性：Ipratropium bromide (Sch 1000) hydrate 是毒蕈碱的受体 (muscarinic receptor) 的拮抗剂，对 M1、M2 和 M3 受体的结合的 IC₅₀ 值分别为 2.9 nM、2 nM 和 1.7 nM。Ipratropium bromide hydrate 具有放松平滑肌的作用，可用于慢性阻塞性肺病 (COPD) 和哮喘等研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vitro: Ipratropium bromide hydrate (1 nM, 10 nM, 100 nM; 15 min) exerts its toxic effects via disruption of mitochondrial membrane potential.
Ipratropium bromide hydrate (1 nM-1 μM; 4 h) increases infarct size in isolated perfused heart ischaemia/reperfusion experiments with a dose-responsive manner (EC₅₀=22.7 nM).
Ipratropium bromide hydrate (0.001 nM-0.1 mM; 2 h) inhibits adult rat cardiac myocyte growth after 4 h hypoxia treatment.

In Vivo: Ipratropium bromide hydrate (1.0 μg/kg; i.v.; single dose) enhances vagal nerve stimulation induing bronchoconstriction.
Ipratropium bromide hydrate (0.04 mg/20 mL ａnd 0.20 mg/20 mL; inhalation for 30 min, rate=30 mL/30 min) can protect the lungs against the cadmium-induced acute neutrophilic inflammation by reducing the parenchyma inflammatory infiltration of neutrophils.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Parkinson＇s Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Children’s Drug Library  |  VU0357017 hydrochloride  |  TBPB  |  Imidafenacin  |  (±)-Muscarine chloride  |  mAChR-IN-1 hydrochloride  |  Scopolamine butylbromide  |  Navafenterol  |  Fustin  |  Penehyclidine  |  VU 0255035  |  DREADD agonist 21  |  Umeclidinium-d5 bromide  |  Cevimeline  |  Metixene hydrochloride  |  Methacholine bromide  |  Iperoxo  |  VU0467485  |  M4 mAChR agonist-1  |  Clozapine  |  Brompheniramine maleate  |  Umeclidinium bromide  |  Zamifenacin fumarate  |  (-)-Cevimeline hydrochloride hemihydrate  |  LY2119620  |  LY2119620-d3  |  Isopteropodine  |  VU 0238429  |  (Rac)-5-Hydroxymethyl Tolterodine-d14

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。