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Spectinomycin

CAS No. : 1695-77-8

MCE 站：Spectinomycin

产品活性：Spectinomycin 是一种广谱抗生素，可以抑制多种革兰氏阳性和革兰氏阴性细菌的生长。Spectinomycin 通过特异靶向细菌核糖体，干扰蛋白质合成。Spectinomycin 也是 td 内含子 RNA 的非竞争性抑制剂。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Bacterial

In Vitro: Spectinomycin selectively inhibits protein synthesis in cells ａnd in extracts of Escherichia coli.
Spectinomycin (50 μg/mL) inhibits Escherichia coli growth rapidly ａnd reversibly, ａnd suppresses amino acid incorporation immediately.
Spectinomycin (1 μg/mL or 3 μM) inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA, with maximum inhibition of 70-80% in extracts of Escherichia coli.
Spectinomycin blocks the translocation of peptidyl-tRNAs from A-site to P-site by inhibiting the binding of elongation factor G to the ribosome.
Spectinomycin interacts specifically with the residues G1064 ａnd 01192 in 16S rRNA ａnd potentially makes it inactive.
Spectinomycin exhibits splicing inhibition ａnd dependent on pH changes ａnd Mg²⁺ concentration, indicating electrostatic interactions with the intron RNA.

In Vivo: Spectinomycin (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) shows the safety in healthy chicks.
Spectinomycin (10 mg/kg; i.v.; single dose) has the major elimination pathway by renal excretion, approximately 55% is excreted into the urine in unchanged form.
Pharmacokinetics of Spectinomycin in Rat

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