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Dacarbazine citrate

CAS No. : 64038-56-8

MCE 站：Dacarbazine citrate

产品活性：Dacarbazine citrate 是一种细胞周期非特异性抗肿瘤烷基化剂。Dacarbazine citrate 抑制 T 和 B 淋巴细胞反应，IC₅₀ 分别为 50 和 10 μg/mL。Dacarbazine citrate 可用于凋亡和多种癌症如转移性恶性黑色素瘤的研究。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: Dacarbazine citrate has less pronounced inhibition of mitogenesis with IC₅₀ values of 50 ａnd 10 μg/mL for T ａnd B cells, respectively.
Dacarbazine citrate (30 μM, 0-14 min) evokes a concentration-dependent calcium response in hTRPA1-HEK293 cells with an EC₅₀ value of 23 μM ａnd selectively activates the human TRPA1 channel.
Dacarbazine citrate (100-10,000 μM, 24 h) has cytotoxic action on B16-F10 melanoma cells.

In Vivo: Dacarbazine citrate (1 mg/kg, i.p.) evokes a concentration-dependent calcium response ａnd the maximum calcium response with an EC₅₀ value of 16 μM in a subset of cells of cultured mouse DRG neurons ａnd excites TRPA1 in rodent sensory neurons.
Dacarbazine citrate (1 mg/kg, i.p.; 1, 3, 5 ａnd 7 days for chronic pain or 1 mg/kg, i.p. for acute treatment) induces mechanical ａnd cold allodynia in mice.
Dacarbazine citrate-induced nociception can be reduced by TRPA1-deficient mice ａnd antisense oligonucleotide for the TRPA1 receptor.
Dacarbazine citrate-induced chronic nociception can be reduced by selective TRPA1 receptor antagonists ａnd antioxidants.
Dacarbazine citrate-induced nociception can be resisted by RPA1 antagonist or an antioxidant in a tumor-associated cancer pain model.

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