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Zn-DPA-maytansinoid conjugate 1

CAS No. :

MCE 站：Zn-DPA-maytansinoid conjugate 1

产品活性：Zn-DPA-maytansinoid conjugate 1 是一种类美坦素偶联物，靶向小分子免疫检查点。Zn-DPA-maytansinoid conjugate 1 可诱导肿瘤生长持续消退，使肿瘤微环境 (TME) 恢复活力、变成“发炎热肿瘤”。

研究领域：Cell Cycle/DNA Damage  |  JAK/STAT Signaling  |  Stem Cell/Wnt  |  GPCR/G Protein  |  Immunology/Inflammation

作用靶点：Checkpoint Kinase (Chk)  |  STAT  |  CXCR  |  CCR

In Vitro: Zn-DPA-maytansinoid conjugate 1 (compound 40a) (0-20 mM; 72 h) inhibits the growth of human pancreatic cancer MIA PaCa2 cells ａnd triple-negative breast cancer HCC1806 cells ａnd displays no effect on normal fibroblast (Detroit 551).
Zn-DPA-maytansinoid conjugate 1 increases CD8⁺ T cell infiltration significantly in the tumor mass that sensitized tumors from the intrinsic immune-suppressive TME.
Zn-DPA-maytansinoid conjugate 1 induces tumor inflammation-related mRNA expression such as STAT1, CXCL10, CCL5, ａnd CCL2.
Zn-DPA-maytansinoid conjugate 1 leads to rejuvenation of TME with enhancement in T cell, macrophage, NK cell, chemokine, ａnd cytokine functions.

In Vivo: Zn-DPA-maytansinoid conjugate 1 (compound 40a) (1-2.5 mg/kg; i.v.; twice a week for 2 weeks) effectively shrank the growth of many solid tumors, exerts antipancreatic cancer, anti-triple-negative breast cancer ａnd anti-sorafenib-resistant HCC tumor activities.

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