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Bisantrene dihydrochloride

CAS No. : 71439-68-4

MCE 站：Bisantrene dihydrochloride

产品活性：Bisantrene dihydrochloride 是高效的抗癌剂，它通过影响 DNA 插入发挥细胞毒性。Bisantrene dihydrochloride 靶向真核生物的拓扑异构酶 II。Bisantrene dihydrochloride 是MDR1 的底物。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: Bisantrene dihydrochloride promots DNase I cleavage at oligopurine-oligopyrimidine tracts ａnd slightly reduces the cleavage activity at alternating purine-pyrimidine sequences.
Bisantrene dihydrochloride is an inhibitor of [³H]uridine incorporation into RNA ａnd [³H]thymidine incorporation into DNA.

In Vivo: Bisantrene dihydrochloride is an antitumor agent active against a number of experimental tumors, including P388 leukemia, L1210 leukemia, Lieberman plasma cell tumor, B16 melanoma, colon tumor 26, ａnd Ridgway osteogenic sarcoma.
Bisantrene dihydrochloride is effective over a dose range of 1.56 to 150 mg/kg depending upon the frequency, route, ａnd schedule of the treatment ａnd the tumor model used.
Bisantrene dihydrochloride (25, 50 ａnd 100 mg/kg; i.p.; once) pretreats with macrophages shows antitumor effect to mice with P815 tumor cells injection.
Bisantrene dihydrochloride (10-150 mg/kg; i.v.; once) dose-dependently induces leukopenia in Neo mice. B cells ａnd macrophages are targets for bisantrene dihydrochloride toxicity.

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