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4′-Hydroxywogonin

CAS No. : 57096-02-3

MCE 站：4′-Hydroxywogonin

产品活性：4′-Hydroxywogonin (8-Methoxyapigenin) 是一种黄酮类化合物，可以从 Scutellaria barbata 和 Verbena littoralis 等多种植物中分离得到。4′-Hydroxywogonin 通过 TAK1/IKK/NF-κB、MAPKs 和 PI3/AKT 信号通路具有抗炎活性。4′-Hydroxywogonin 通过干扰 PI3K/AKT 信号抑制血管生成。4′-Hydroxywogonin 抑制细胞增殖和诱导细胞凋亡 (apoptosis)。

研究领域：NF-κB  |  MAPK/ERK Pathway  |  PI3K/Akt/mTOR  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  Apoptosis

作用靶点：IKK  |  NF-κB  |  p38 MAPK  |  PI3K  |  Akt  |  Reactive Oxygen Species  |  Interleukin Related  |  TNF Receptor  |  Apoptosis  |  Caspase  |  Bcl-2 Family

结构分类：黄酮类  |  黄酮  |  结构分类

来源：植物  |  马鞭草科  |  海滩马鞭草

In Vitro: 4′-Hydroxywogonin (8-Methoxyapigenin; 0.5-15 μM; 0-24 h) has low cytotoxicity ａnd inhibits NO ａnd PGE₂ production in LPS-stimulated RAW 264.7 macrophages by suppression of iNOS ａnd COX-2 expression.
4′-Hydroxywogonin (0.5-15 μM; 1 ａnd 12 h) suppresses LPS-induced expression of pro-inflammatory cytokines in RAW 264.7 macrophages ａnd suppresses LPS-induced activation of NF-κB.
4′-Hydroxywogonin (0.5-15 μM; 1 h) suppresses LPS-induced degradation of IκB-α ａnd activation of IKK ａnd TAK ａnd suppresses the phosphorylation of MAPK ａnd AKTin in RAW 264.7 macrophages.
4′-Hydroxywogonin (0.5-15 μM; 24 h) inhibits ROS production in LPS-stimulated RAW 264.7 macrophages.
4′-Hydroxywogonin (0-10 μg/mL; 24 h) reduces the viability of SW620cells in a concentration- ａnd time-dependent manner ａnd decreases the mRNA ａnd protein expression of vascular endothelial growth factor-A (VEGF-A), the predominant pro-angiogenic cytokine in tumor angiogenesis.
4′-Hydroxywogonin (24 h; SUP-B15 ａnd Jurkat cells) induces apoptosis ａnd decreases the expression of C-MYC, BCL-2 ａnd cleaved caspase 3.

In Vivo: 4′-Hydroxywogonin (10 ａnd 20 mg/kg; i.p.; male C57BL/6 mice) alleviates LPS-induced acute lung injury (ALI) in a mouse model.

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