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4′-Hydroxywogonin
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4′-Hydroxywogonin
CAS No. : 57096-02-3
MCE 站:4′-Hydroxywogonin
产品活性:4′-Hydroxywogonin (8-Methoxyapigenin) 是一种黄酮类化合物,可以从 Scutellaria barbata 和 Verbena littoralis 等多种植物中分离得到。4′-Hydroxywogonin 通过 TAK1/IKK/NF-κB、MAPKs 和 PI3/AKT 信号通路具有抗炎活性。4′-Hydroxywogonin 通过干扰 PI3K/AKT 信号抑制血管生成。4′-Hydroxywogonin 抑制细胞增殖和诱导细胞凋亡 (apoptosis)。
研究领域:NF-κB | MAPK/ERK Pathway | PI3K/Akt/mTOR | Metabolic Enzyme/Protease | Immunology/Inflammation | Apoptosis
作用靶点:IKK | NF-κB | p38 MAPK | PI3K | Akt | Reactive Oxygen Species | Interleukin Related | TNF Receptor | Apoptosis | Caspase | Bcl-2 Family
In Vitro: 4′-Hydroxywogonin (8-Methoxyapigenin; 0.5-15 μM; 0-24 h) has low cytotoxicity and inhibits NO and PGE2 production in LPS-stimulated RAW 264.7 macrophages by suppression of iNOS and COX-2 expression.
4′-Hydroxywogonin (0.5-15 μM; 1 and 12 h) suppresses LPS-induced expression of pro-inflammatory cytokines in RAW 264.7 macrophages and suppresses LPS-induced activation of NF-κB.
4′-Hydroxywogonin (0.5-15 μM; 1 h) suppresses LPS-induced degradation of IκB-α and activation of IKK and TAK and suppresses the phosphorylation of MAPK and AKTin in RAW 264.7 macrophages.
4′-Hydroxywogonin (0.5-15 μM; 24 h) inhibits ROS production in LPS-stimulated RAW 264.7 macrophages.
4′-Hydroxywogonin (0-10 μg/mL; 24 h) reduces the viability of SW620cells in a concentration- and time-dependent manner and decreases the mRNA and protein expression of vascular endothelial growth factor-A (VEGF-A), the predominant pro-angiogenic cytokine in tumor angiogenesis.
4′-Hydroxywogonin (24 h; SUP-B15 and Jurkat cells) induces apoptosis and decreases the expression of C-MYC, BCL-2 and cleaved caspase 3.
In Vivo: 4′-Hydroxywogonin (10 and 20 mg/kg; i.p.; male C57BL/6 mice) alleviates LPS-induced acute lung injury (ALI) in a mouse model.
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热门标签:8-Methoxyapigenin