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HDAC-IN-48

CAS No. :

MCE 站：HDAC-IN-48

产品活性：HDAC-IN-48 是一种强效的 HDAC 抑制剂，是具有细胞毒性的杂交分子。HDAC-IN-48 由 SAHA 和 CETZOLE 分子的药效团组成，可诱导铁死亡 (ferroptosis) 并抑制 HDAC 蛋白。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Apoptosis

作用靶点：HDAC  |  Ferroptosis

In Vitro: HDAC-IN-48 (0-40 μM; 3 d) has superior antiproliferative activity on cancer cells (NCI-H522 ａnd HCT-116) vs the normal cells (WI38 ａnd RPE) with IC₅₀s of 0.5 μM (NCI-H522), 0.61 μM (HCT-116), 8.37 μM (WI38, normal human lung fibroblasts), ａnd 6.13 μM (RPE, retinal pigment epithelial cells), respectively.
HDAC-IN-48 (2.5 μM; 24 h) suppresses cell viability by inducing ferroptosis ａnd HDAC inhibition.
HDAC-IN-48 (10 μM; 6 h) decreases the lipid peroxide level compared with SAHA.
HDAC-IN (0.58 μM, 1.16 μM, ａnd 2.32 μM; 3 d) has no neurotoxic effects ａnd (2.5, 5, ａnd 10 μM; 3 d) leads to hyper acetylation of histones ａnd tubulin.
Nondifferentiated PC-12 cells have stem-like properties, but when differentiated by a nerve growth factor, they demonstrate neuronal behavior. HDAC-IN-48 (0.58 μM, 1.16 μM, ａnd 2.32 μM; 24 h) behaves as the HDAC control effect, shows few ferroptosis induction on both differentiated ａnd undifferentiated PC-12 cells.

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