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Farnesyl pyrophosphate

CAS No. : 13058-04-3

MCE 站：Farnesyl pyrophosphate

产品活性：Farnesyl pyrophosphate 是一种 15 碳类异戊二烯，是甲羟戊酸 (MVA) 途径的代谢中间体。Farnesyl pyrophosphate 是一种 TRPM2 (TRP Channel) 激动剂，可激活 TRPM2 打开，使离子流入到细胞内。Farnesyl pyrophosphate 是胆固醇合成、泛醌合成、蛋白质法尼基化修饰和香叶基-香叶基焦磷酸 (GGPP) 合成的关键分支底物。

研究领域：Neuronal Signaling  |  Membrane Transporter/Ion Channel  |  Metabolic Enzyme/Protease

作用靶点：TRP Channel  |  Endogenous Metabolite

In Vitro: Farnesyl pyrophosphate functions as an identified danger signal to trigger acute cell death leading to neuron loss in stroke. Harboring both a hydrophobic 15-carbon isoprenyl chain ａnd a heavily charged pyrophosphate head, Farnesyl pyrophosphate leads to acute cell death independent of its downstream metabolic pathways. Mechanistically, extracellular calcium influx ａnd the cation channel transient receptor potential melastatin 2 (TRPM2) exhibit essential roles in Farnesyl pyrophosphate-induced cell death. Farnesyl pyrophosphate activates TRPM2 opening for ion influx.

In Vivo: In terms of a mouse model constructing by middle cerebral artery occlusion (MCAO), Farnesyl pyrophosphate accumulates in the brain, which indicates the function of the Farnesyl pyrophosphate ａnd TRPM2 danger signal axis in ischemic injury. Farnesyl pyrophosphate/TRPM2 signaling axis ａnd the MVA pathway exhibit important roles in brain ischemia ａnd potentially neurodegenerative diseases.

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