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Patritumab

CAS No. : 1262787-83-6

MCE 站：Patritumab

产品活性：Patritumab (Human Anti-ERBB3 Recombinant Antibody) 是针对 ERBB3 的中和性单克隆抗体。Patritumab与 Cetuximab (HY-P9905) 具有协同作用，可有效抑制 EGFR，HER2，HER3，ERK 和 AKT 的磷酸化。Patritumab 也能诱导细胞凋亡 (apoptosis)，也抑制胰腺、非小细胞肺癌和结直肠癌异种移植物肿瘤的生长。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK  |  PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  MAPK/ERK Pathway  |  Cell Cycle/DNA Damage  |  Epigenetics  |  Apoptosis

作用靶点：EGFR  |  Akt  |  ERK  |  PARP  |  Survivin

In Vitro: Patritumab targets to the extracellular domain (ECD) of HER3 ａnd (10 μg/mL; 5 d) induces DiFi-HRG4 cells apoptosis.
Patritumab (10 μg/mL; 6 h) markedly inhibits the phosphorylation of HER3 ａnd AKT, without affecting that of ERK, in DiFi-HRG4 cells.
Patritumab (10 μg/mL; 48 h) also induces the cleavage of PARP accompanied with both up-regulation of BIM ａnd down-regulation of survivin expression.

In Vivo: Patritumab (1 mg/mouse; i.p.; twice a week for 4 weeks) combines with 1 mg Cetuximab ａnd restores Cetuximab sensitivity in DiFi-HRG tumor xenografts model in mice.
Heregulin produced by colorectal cancer tumors harboring wild-type KRAS induces Cetuximab resistance, ａnd that combination therapy with cetuximab ａnd patritumab overcomes such resistance in vivo.

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