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Danshenol A

CAS No. : 189308-08-5

MCE 站：Danshenol A

产品活性：Danshenol A 是一种松香类二萜类化合物，是一种醛糖还原酶 (AR) 抑制剂，IC₅₀ 为 0.1 μM。Danshenol A 可以通过直接清除 ROS 来保护内皮细胞免受氧化应激。Danshenol A 具有抗炎和抗肿瘤特性，可用于动脉粥样硬化研究。

研究领域：Metabolic Enzyme/Protease  |  NF-κB  |  Immunology/Inflammation

作用靶点：Aldose Reductase  |  Reactive Oxygen Species

结构分类：萜类  |  二萜

来源：植物  |  菊科  |  泥胡菜  |  植物  |  唇形科

In Vitro: Danshenol A (10nM; pretreatment for 1h) alone showed no effect on the ICAM-1 expression at both mRNA ａnd protein levels. TNF-α-induced ICAM-1 expression ａnd subsequent adhesion of monocytes, as well as elevated reactive oxygen species (ROS) generation ａnd NOX4 expression are all significantly reversed by Danshenol ADanshenol A inhibits TNF-α-induced ICAM-1 expression ａnd subsequent monocyte adhesion to endothelial cells through the NOX4-dependent IKKβ/NF-κB pathway.
Danshenol A (1, 3, ａnd 10 μM; pretreated for 35min) restores apoptosis of cardiomyocytes induced by angiotensin II. Besides, Danshenol A inhibits mitochondrial redox signaling pathways in cardiomyocytes.
Danshenol A shows inhibited growth of K562 (IC₅₀ = 0.53 μg/mL), T-24 (IC₅₀ = 7.94 μg/mL), QGY (IC₅₀ = 4.65 μg/mL) ａnd Me180 (IC₅₀ = 6.89 μg/mL) cell lines.

In Vivo: Danshenol A (0.3-3mg/kg; p.o; daily; for 12 weeks) ameliorates blood pressure, cardiac injury, ａnd myocardial collagen volume ａnd improved cardiac function in SHR rats. Danshenol A repaires the structure/function of the mitochondria, alleviated oxidative stress in the myocardium.

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