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Hirudin

CAS No. : 8001-27-2

MCE 站：Hirudin

产品活性：Hirudin 是一种具有抗凝血特性的凝血酶抑制剂。Hirudin 具有较强的抗血栓、伤口修复、抗纤维化、抗肿瘤和抗高尿酸血症作用。Hirudin 还会影响糖尿病并发症、脑出血等。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Thrombin  |  Apoptosis

In Vitro: Hirudin inhibits the activity of thrombin, deprives the ability of thrombin to cleave fibrinogen, prevents the formation of fibrin ａnd the cross-linking polymerization process of fibrin monomer in internal ａnd external coagulation pathway.
Hirudin reduces cell apoptosis of human microvascular endothelial cells (HMVECs) ａnd suppresses the expression of p-JAK2 via antagonizing thrombin.
Hirudin inhibits VEGF-Notch pathway ａnd cell proliferation of HMVECs at high doses.
Hirudin (3-10 mg/mL) reverses the abnormal proliferation ａnd fibrosis in HK-2 cells caused by TGF-β1.
Hirudin depresses the myocardial fibroblasts induced by angiotensin II by dose-dependently inhibits oxidative stress, regulates fibrosis-related factors, ａnd represses the ERK1/2 pathway.

In Vivo: Hirudin increases the viability of rat random skin flap ａnd reduces inflammatory responses.
Hirudin promotes the wound healing in SD rats after laser surgery.
Hirudin (10 ａnd 15 mg/kg; i.g. once daily for 21 days) improves renal interstitial fibrosis to reduce renal tubule injury ａnd inflammation in unilateral ureteral obstruction (UUO) mice.

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